The role of QSAR in dopamine interactions

Corwin Hansch; Rajeshwar P Verma; Alka Kurup; Suresh B Mekapati

doi:10.1016/j.bmcl.2005.02.012

The role of QSAR in dopamine interactions

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2149-57. doi: 10.1016/j.bmcl.2005.02.012.

Authors

Corwin Hansch¹, Rajeshwar P Verma, Alka Kurup, Suresh B Mekapati

Affiliation

¹ Department of Chemistry, Pomona College, Claremont, CA 91711, USA. atessier@pomona.edu <atessier@pomona.edu>

PMID: 15808487
DOI: 10.1016/j.bmcl.2005.02.012

Abstract

Dopamine receptor blockers have been used for the treatment of schizophrenia for many years. We have developed 22 quantitative structure activity relationships (QSAR) for different sets of compounds to understand chemical-biological interactions governing their activities toward dopamine receptors.

MeSH terms

Dopamine Agents / chemistry*
Dopamine Agents / metabolism*
Dopamine Antagonists / metabolism
Dopamine Antagonists / pharmacology
Dopamine D2 Receptor Antagonists
Haloperidol / analogs & derivatives
Haloperidol / metabolism
Humans
Protein Binding / physiology
Quantitative Structure-Activity Relationship*
Receptors, Dopamine D2 / metabolism*
Receptors, Dopamine D4

Substances

DRD4 protein, human
Dopamine Agents
Dopamine Antagonists
Dopamine D2 Receptor Antagonists
Receptors, Dopamine D2
Receptors, Dopamine D4
Haloperidol